A method for preventing, treating, or ameliorating a medical condition, comprising administering to a mammalian subject a therapeutically effective amount of the polypeptide of claim 1 1 or the polynucleotide of claim 1.(a) determining the presence or absence of a mutation in the polynucleotide of claim 1 ; and (b) diagnosing a pathological condition or a susceptibility to a pathological condition based on the presence or absence of said mutation.19.
A method of diagnosing a pathological condition or a susceptibility to a pathological condition in a subject comprising: (a) determining the presence or amount of expression of the polypeptide of claim 1 1 in a biological sample; and Human Pancreas and Pancreatic Cancer Associated Gene Sequences and Polypeptides Field of the Invention This invention relates to newly identified pancreas or pancreatic cancer related polynucleotides and the polypeptides encoded by these polynucleotides herein collectively known as "pancreatic cancer antigens," and to the complete gene sequences associated therewith and to the expression products thereof, as well as the use of such pancreatic cancer antigens for detection, prevention and treatment of disorders of the pancreas, particularly the presence of pancreatic cancer.
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Of these disorders, those characterized by structural deformities are termed "congenital anomalies" and involve defects in a developing fetus. Any substance that causes birth defects is known as a teratogen.
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Spina bifida describes birth defects caused by an incomplete closure of one or more vertebral arches of the spine, resulting in malformations of the spinal cord.
The spinal membranes and spinal cord may protrude through the absence of vertebral arches (called clefts).