Updating the concept of prebiotics

“Interactions between Gut Microbiota and Host Metabolism Predisposing to Obesity and Diabetes.” Annual Review of Medicine 62 (2011): 361–80. Abstract »Sonnenburg, Justin L, Jian Xu, Douglas D Leip, Chien-Huan Chen, Benjamin P Westover, Jeremy Weatherford, Jeremy D Buhler, and Jeffrey I Gordon. 5 (November 2009): 1236–43, doi:10.3945/ajcn.2009.28095. Full Text »Jill Parnell and Raylene Reimer, “Weight Loss during Oligofructose Supplementation Is Associated with Decreased Ghrelin and Increased Peptide YY in Overweight and Obese Adults,” American Journal of Clinical Nutrition 89, no. Full Text »Marc R Bomhof et al., “Combined Effects of Oligofructose and Bifidobacterium Animalis on Gut Microbiota and Glycemia in Obese Rats.,” Obesity (Silver Spring, Md.) 22, no. 6 (June 6, 2005): 1000–1007, doi:10.1038/oby.2005.117. and Dasylirion Spp.,” British Journal of Nutrition 99, no. 10 (October 2006): 814–19, doi:10.1136/adc.2006.098251. Full Text »Consumption of prebiotic inulin enriched with oligofructose in combination with the probiotics Lactobacillus rhamnosus and Bifidobacterium lactis has minor effects on selected immune parameters in polypectomised and colon cancer patients. “Think Globally, Act Locally: Regulated Deployment of Polysaccharide Degradation Abilities by our Symbiotic Gut Bacteria.” The FASEB Journal 29, no. Abstract »Musso, Giovanni, Roberto Gambino, and Maurizio Cassader. Abstract »Bridie J Archer et al., “Effect of Fat Replacement by Inulin or Lupin-Kernel Fibre on Sausage Patty Acceptability, Post-Meal Perceptions of Satiety and Food Intake in Men.,” The British Journal of Nutrition 91, no. Full Text »Patrice D Cani et al., “Gut Microbiota Fermentation of Prebiotics Increases Satietogenic and Incretin Gut Peptide Production with Consequences for Appetite Sensation and Glucose Response after a Meal.,” The American Journal of Clinical Nutrition 90, no. Cani et al., “Oligofructose Promotes Satiety in Rats Fed a High-Fat Diet: Involvement of Glucagon-Like Peptide-1,” Obesity Research 13, no. Urías-Silvas et al., “Physiological Effects of Dietary Fructans Extracted from Agave Tequilana Gto. 2 (February 2005): 242–49, doi:10.1136/gut.2004.044834. Full Text »Gori, A., Rizzardini, G., Van’t Land, B., Amor, K. 3 (March 2006): 348–55, doi:10.1136/gut.2005.074971. Full Text »G Moro et al., “A Mixture of Prebiotic Oligosaccharides Reduces the Incidence of Atopic Dermatitis during the First Six Months of Age.,” Archives of Disease in Childhood 91, no. “The Microbiome and Butyrate Regulate Energy Metabolism and Autophagy in the Mammalian Colon.” Cell Metabolism 13, no. “Keeping Bugs in Check: The Mucus Layer as a Critical Component in Maintaining Intestinal Homeostasis.” IUBMB Life, 2015. Full Text »Jakobsson, Hedvig E, Ana M Rodríguez-Piñeiro, André Schütte, Anna Ermund, Preben Boysen, Mats Bemark, Felix Sommer, Fredrik Bäckhed, Gunnar C Hansson, and Malin Ev Johansson. ,” The British Journal of Nutrition 109 Suppl (2013): S81–85, doi:10.1017/S0007114512004047. 4 (April 2007): 676–84, doi:10.1017/S0007114507450292. Full Text »E J Schiffrin et al., “Systemic Inflammatory Markers in Older Persons: The Effect of Oral Nutritional Supplementation with Prebiotics.,” The Journal of Nutrition, Health & Aging 11, no. Abstract »Petra A M J Scholtens et al., “Fecal Secretory Immunoglobulin A Is Increased in Healthy Infants Who Receive a Formula with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides.,” The Journal of Nutrition 138, no. Full Text »Mayank Thakur et al., “Characterization and in Vitro Immunomodulatory Screening of Fructo-Oligosaccharides of Asparagus Racemosus Willd.,” International Journal of Biological Macromolecules 50, no. K Buddington, “Dietary Oligofructose and Inulin Modulate Immune Functions in Mice,” Nutrition Research 23, no. Full Text »Faderl, Martin, Mario Noti, Nadia Corazza, and Christoph Mueller. “Prioritization of a Plant Polysaccharide over a Mucus Carbohydrate Is Enforced by a Bacteroides Hybrid Two-Component System.” Molecular Microbiology 85, no. “Glycan Foraging in Vivo by an Intestine-Adapted Bacterial Symbiont.” Science (New York, N. 02 (August 22, 2007): 254–61, doi:10.1017/S0007114507795338. Full Text »Patrice D Cani and Nathalie M Delzenne, “Interplay between Obesity and Associated Metabolic Disorders: New Insights into the Gut Microbiota.,” Current Opinion in Pharmacology 9, no. Full Text »Lorenza Conterno et al., “Obesity and the Gut Microbiota: Does up-Regulating Colonic Fermentation Protect against Obesity and Metabolic Disease? 3 (August 11, 2011): 241–60, doi:10.1007/s12263-011-0230-1. Abstract »Nathalie M Delzenne, Audrey M Neyrinck, and Patrice D Cani, “Gut Microbiota and Metabolic Disorders: How Prebiotic Can Work? Monika Roller et al., “Consumption of Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus Rhamnosus and Bifidobacterium Lactis Has Minor Effects on Selected Immune Parameters in Polypectomised and Colon Cancer Patients.,” The British Journal of Nutrition 97, no.

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Certain gut bacteria are also able to produce compounds similar to human hormones.

Donohoe, Dallas R., Nikhil Garge, Xinxin Zhang, Wei Sun, Thomas M. Suppl 2 (August 1, 2010): S1–63, doi:10.1017/S0007114510003363. 3 (March 2009): 484–87, doi:10.1111/j.1398-9995.2008.01765.x. Full Text »Jelena Vulevic et al., “Modulation of the Fecal Microflora Profile and Immune Function by a Novel Trans-Galactooligosaccharide Mixture (B-GOS) in Healthy Elderly Volunteers.,” The American Journal of Clinical Nutrition 88, no. 01 (June 23, 2011): 96–105, doi:10.1017/S0007114511002637. Full Text »Bastiaan Schouten et al., “Oligosaccharide-Induced Whey-Specific CD25( ) Regulatory T-Cells Are Involved in the Suppression of Cow Milk Allergy in Mice.,” The Journal of Nutrition 140, no.

“The Composition of the Gut Microbiota Shapes the Colon Mucus Barrier.” EMBO Reports 16 (2015): 164–77. Full Text »Jill A Parnell and Raylene A Reimer, “Prebiotic Fiber Modulation of the Gut Microbiota Improves Risk Factors for Obesity and the Metabolic Syndrome.,” Gut Microbes 3, no. Full Text »Marcel Roberfroid et al., “Prebiotic Effects: Metabolic and Health Benefits.,” The British Journal of Nutrition 104 Suppl , no. 1 (January 1, 2012): 77–81, doi:10.1016/j.ijbiomac.20. Abstract »Nachum Vaisman et al., “Short-Term Effect of Prebiotics Administration on Stool Characteristics and Serum Cytokines Dynamics in Very Young Children with Acute Diarrhea.,” Nutrients 2, no. Full Text »E van Hoffen et al., “A Specific Mixture of Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides Induces a Beneficial Immunoglobulin Profile in Infants at High Risk for Allergy.,” Allergy 64, no. 2 (February 2003): 257–67, doi:10.1016/S0271-5317(02)00516-X. Abstract »Hiroyuki Mizubuchi et al., “Isomalto-Oligosaccharides Polarize Th1-like Responses in Intestinal and Systemic Immunity in Mice.,” The Journal of Nutrition 135, no. Full Text »Monika Roller, Gerhard Rechkemmer, and Bernhard Watzl, “Prebiotic Inulin Enriched with Oligofructose in Combination with the Probiotics Lactobacillus Rhamnosus and Bifidobacterium Lactis Modulates Intestinal Immune Functions in Rats.,” The Journal of Nutrition 134, no. Full Text »Bastiaan Schouten et al., “A Potential Role for CD25 Regulatory T-Cells in the Protection against Casein Allergy by Dietary Non-Digestible Carbohydrates,” British Journal of Nutrition 107, no.

Then, she heard about this guy, Nathan Pritikin, one of our early lifestyle medicine pioneers, and what happened next is chronicled in Pritikin’s biography. Greger had heart disease, angina, and claudication; her condition was so bad she could no longer walk without great pain in her chest and legs. If effectively, the cure to our #1 killer could get lost down some rabbit hole and ignored, what else might there be in the medical literature that could help my patients—but just didn’t have a corporate budget driving its promotion? For those of you unfamiliar with my work, every year, I read through every issue of every English-language nutrition journal in the world—so busy folks like you don’t have to. It’s strictly non-commercial—I’m not selling anything. I just put it up as a public service, as a labor of love, as a tribute to my grandmother.

My grandma was one of the “death’s door people.” Like Frances Greger, my grandmother. Within three weeks [though], she was not only out of her wheelchair…[she] was walking ten miles a day.” This is a picture of my grandma—at her grandson’s wedding, 15 years after doctors had abandoned her to die. Dean Ornish published his Lifestyle Heart Trial years later, proving, with something called quantitative angiography, that indeed heart disease could be reversed in the majority of patients without drugs, without surgery—just a plant-based diet and other healthy lifestyle behaviors— I assumed this was going to be the game-changer. But here it was in black and white, published in one of the most prestigious medical journals. I then compile all the most interesting, the most groundbreaking, the most practical findings to create new videos and articles for my nonprofit site, Nutrition I hope I can do for your family what Pritikin did for my family.